| ncRNA Symbol: | PLOD3 |
| Full Name: | procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 |
| Category: | mRNA |
| Synonyms: | LH3 |
| Chromosome: | chr7 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 101205977 | End Site(bp): | 101218420 |
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| Gene Summary: | The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008] |
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