Entry Detail



General Information

Database ID:BRCA00147
Cancer Type:breast cancer
Dataset:GSE109761
CTCs/CTM Isolation Method:microfluidics immunofluorescence



Gene Information

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:lncRNA
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:chr11
Strand:+
Coordinate:
Start Site(bp):65497762End Site(bp):65506516
Gene Summary:This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]
External Links:
Ensembl ID:ENSG00000251562
HGNC ID:HGNC:29665
Entrez Gene:378938



Expression Profile of MALAT1 Gene

 







Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
miRNA targets:NA
Display: