| ncRNA Symbol: | COX4I1 |
| Full Name: | cytochrome c oxidase subunit 4I1 |
| Category: | mRNA |
| Synonyms: | COX IV-1|COX4|COX4-1|COXIV|COXIV-1 |
| Chromosome: | chr16 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 85798633 | End Site(bp): | 85807044 |
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| Gene Summary: | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
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