ctcRbase

Entry Detail

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General Information

Database ID: BRCA00938 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: NPM1 Full Name: nucleophosmin 1 Category: mRNA Synonyms: B23|NPM Chromosome: chr5 Strand: + Coordinate: Start Site(bp): 171387116 End Site(bp): 171411137 Gene Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017] External Links: Ensembl ID: ENSG00000181163 HGNC ID: HGNC:7910 Entrez Gene: 4869

Expression Profile of NPM1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-1271-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-17-5p YES YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-195-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-208a-3p YES YES YES hsa-miR-208b-3p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-23a-3p YES YES YES hsa-miR-23b-3p YES YES YES hsa-miR-302a-3p YES YES YES hsa-miR-302b-3p YES YES YES hsa-miR-302c-3p YES YES YES hsa-miR-302d-3p YES YES YES hsa-miR-302e YES YES YES hsa-miR-31-5p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-372-3p YES YES YES hsa-miR-373-3p YES YES YES hsa-miR-378a-3p YES YES NO hsa-miR-422a YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-429 YES YES YES hsa-miR-487a-3p YES NO YES hsa-miR-490-3p YES YES YES hsa-miR-495-3p YES YES YES hsa-miR-497-5p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES YES hsa-miR-520b YES YES YES hsa-miR-520c-3p YES YES YES hsa-miR-520d-3p YES YES YES hsa-miR-520e YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-543 YES YES YES hsa-miR-653-5p YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-9-5p YES NO YES hsa-miR-96-5p YES YES NO Display: