ctcRbase

Entry Detail

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General Information

Database ID: BRCA00951 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: ERBB3 Full Name: erb-b2 receptor tyrosine kinase 3 Category: mRNA Synonyms: ErbB-3|FERLK|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 56079857 End Site(bp): 56103505 Gene Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000065361 HGNC ID: HGNC:3431 Entrez Gene: 2065

Expression Profile of ERBB3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-124-3p YES YES NO hsa-miR-125a-5p YES YES YES hsa-miR-125b-5p YES YES YES hsa-miR-1271-5p YES YES NO hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-143-3p YES YES YES hsa-miR-145-5p YES YES YES hsa-miR-148a-3p YES NO YES hsa-miR-148b-3p YES NO YES hsa-miR-149-5p YES YES NO hsa-miR-152-3p YES NO YES hsa-miR-17-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-204-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-211-5p YES YES NO hsa-miR-219a-2-3p YES NO YES hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-22-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-299-5p YES NO YES hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-519d-3p YES YES YES hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-599 YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-96-5p YES YES NO Display: