ctcRbase

Entry Detail

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General Information

Database ID: BRCA01075 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: KPNA2 Full Name: karyopherin subunit alpha 2 Category: mRNA Synonyms: IPOA1|QIP2|RCH1|SRP1-alpha|SRP1alpha Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 68035519 End Site(bp): 68046842 Gene Summary: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] External Links: Ensembl ID: ENSG00000182481 HGNC ID: HGNC:6395 Entrez Gene: 3838

Expression Profile of KPNA2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p NO YES YES hsa-miR-106b-5p NO YES YES hsa-miR-1297 NO YES YES hsa-miR-144-3p NO YES YES hsa-miR-17-5p NO YES YES hsa-miR-20a-5p NO YES YES hsa-miR-20b-5p NO YES YES hsa-miR-221-3p NO YES YES hsa-miR-222-3p NO YES YES hsa-miR-26a-5p NO YES YES hsa-miR-26b-5p NO YES YES hsa-miR-302a-3p NO YES YES hsa-miR-302b-3p NO YES YES hsa-miR-302c-3p NO YES YES hsa-miR-302d-3p NO YES YES hsa-miR-302e NO YES YES hsa-miR-372-3p NO YES YES hsa-miR-373-3p NO YES YES hsa-miR-376c-3p NO YES YES hsa-miR-411-5p NO YES YES hsa-miR-495-3p NO YES YES hsa-miR-519d-3p NO YES YES hsa-miR-520a-3p NO YES YES hsa-miR-520b NO YES YES hsa-miR-520c-3p NO YES YES hsa-miR-520d-3p NO YES YES hsa-miR-520e NO YES YES hsa-miR-93-5p NO YES YES Display: