| ncRNA Symbol: | ATF4 |
| Full Name: | activating transcription factor 4 |
| Category: | mRNA |
| Synonyms: | CREB-2|CREB2|TAXREB67|TXREB |
| Chromosome: | chr22 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 39519695 | End Site(bp): | 39522685 |
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| Gene Summary: | This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] |
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