ctcRbase

Entry Detail

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General Information

Database ID: BRCA01479 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PCBP2 Full Name: poly(rC) binding protein 2 Category: mRNA Synonyms: HNRNPE2|HNRPE2|hnRNP-E2 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 53452102 End Site(bp): 53481162 Gene Summary: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018] External Links: Ensembl ID: ENSG00000197111 HGNC ID: HGNC:8648 Entrez Gene: 5094

Expression Profile of PCBP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-129-5p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-145-5p NO YES YES hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-24-3p NO YES YES hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-421 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-455-3p YES NO YES hsa-miR-490-3p YES YES YES hsa-miR-519d-3p YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-93-5p YES YES NO Display: