ctcRbase

Entry Detail

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General Information

Database ID: BRCA01549 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: TPM1 Full Name: tropomyosin 1 Category: mRNA Synonyms: C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 63042632 End Site(bp): 63071915 Gene Summary: This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000140416 HGNC ID: HGNC:12010 Entrez Gene: 7168

Expression Profile of TPM1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-1271-5p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-1323 YES NO NO hsa-miR-141-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-219a-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-300 YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-495-3p YES NO NO hsa-miR-496 YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-542-3p YES YES YES hsa-miR-548o-3p YES NO NO hsa-miR-653-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-96-5p YES YES YES Display: