ctcRbase

Entry Detail

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General Information

Database ID: BRCA01718 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PLOD1 Full Name: procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Category: mRNA Synonyms: EDS6|EDSKCL1|LH|LH1|LLH|PLOD Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 11934205 End Site(bp): 11975538 Gene Summary: Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000083444 HGNC ID: HGNC:9081 Entrez Gene: 5351

Expression Profile of PLOD1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-140-5p YES NO YES hsa-miR-145-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-335-5p YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-7-5p YES YES NO Display: