ctcRbase

Entry Detail

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General Information

Database ID: BRCA01726 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: YWHAE Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Category: mRNA Synonyms: 14-3-3E|HEL2|KCIP-1|MDCR|MDS Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 1344272 End Site(bp): 1400378 Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008] External Links: Ensembl ID: ENSG00000108953 HGNC ID: HGNC:12851 Entrez Gene: 7531

Expression Profile of YWHAE Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-1297 YES NO YES hsa-miR-135a-5p YES YES NO hsa-miR-135b-5p YES YES NO hsa-miR-141-3p YES YES NO hsa-miR-155-5p YES YES YES hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-26a-5p YES NO YES hsa-miR-26b-5p YES NO YES hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-490-3p YES NO YES hsa-miR-494-3p YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-503-5p YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-873-5p YES YES YES hsa-miR-98-5p YES YES NO Display: