ctcRbase

Entry Detail

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General Information

Database ID: BRCA01741 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: TP53 Full Name: tumor protein p53 Category: mRNA Synonyms: BCC7|BMFS5|LFS1|P53|TRP53 Chromosome: chr17 Strand: - Coordinate: Start Site(bp): 7661779 End Site(bp): 7687550 Gene Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] External Links: Ensembl ID: ENSG00000141510 HGNC ID: HGNC:11998 Entrez Gene: 7157

Expression Profile of TP53 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-143-3p YES YES NO hsa-miR-150-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-22-3p YES YES YES hsa-miR-27a-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-379-5p NO YES YES hsa-miR-410-3p YES YES NO hsa-miR-98-5p NO YES YES Display: