ctcRbase

Entry Detail

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General Information

Database ID: BRCA01763 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: KDELR2 Full Name: KDEL endoplasmic reticulum protein retention receptor 2 Category: mRNA Synonyms: ELP-1|ERD2.2 Chromosome: chr7 Strand: - Coordinate: Start Site(bp): 6445953 End Site(bp): 6484242 Gene Summary: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000136240 HGNC ID: HGNC:6305 Entrez Gene: 11014

Expression Profile of KDELR2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-1323 YES NO NO hsa-miR-138-5p NO YES YES hsa-miR-1-3p YES YES YES hsa-miR-142-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-186-5p YES YES YES hsa-miR-206 YES YES YES hsa-miR-31-5p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES YES hsa-miR-520f-3p YES NO YES hsa-miR-548o-3p YES NO NO hsa-miR-599 YES YES NO hsa-miR-613 YES YES YES hsa-miR-655-3p YES NO YES hsa-miR-758-3p YES YES NO hsa-miR-7-5p YES YES NO hsa-miR-873-5p YES YES NO Display: