ctcRbase

Entry Detail

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General Information

Database ID: BRCA01798 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SF3B1 Full Name: splicing factor 3b subunit 1 Category: mRNA Synonyms: Hsh155|MDS|PRP10|PRPF10|SAP155|SF3b155 Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 197389784 End Site(bp): 197435091 Gene Summary: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000115524 HGNC ID: HGNC:10768 Entrez Gene: 23451

Expression Profile of SF3B1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-133a-3p YES YES NO hsa-miR-133b YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-141-3p NO YES YES hsa-miR-145-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-15a-5p NO YES YES hsa-miR-15b-5p NO YES YES hsa-miR-16-5p NO YES YES hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-18a-5p YES YES NO hsa-miR-18b-5p YES YES NO hsa-miR-193a-3p YES YES YES hsa-miR-193b-3p YES YES YES hsa-miR-195-5p NO YES YES hsa-miR-197-3p YES YES NO hsa-miR-200a-3p NO YES YES hsa-miR-204-5p YES YES YES hsa-miR-206 YES YES NO hsa-miR-211-5p YES YES YES hsa-miR-340-5p NO YES YES hsa-miR-374a-5p YES YES NO hsa-miR-374b-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-424-5p NO YES YES hsa-miR-425-5p YES YES NO hsa-miR-452-5p YES NO YES hsa-miR-495-3p YES YES NO hsa-miR-497-5p NO YES YES hsa-miR-499a-5p NO YES YES hsa-miR-543 YES YES NO hsa-miR-613 YES YES NO hsa-miR-876-5p YES YES YES Display: