ctcRbase

Entry Detail

---



General Information

Database ID: BRCA01854 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: APH1A Full Name: aph-1 homolog A, gamma-secretase subunit Category: mRNA Synonyms: 6530402N02Rik|APH-1|APH-1A|CGI-78 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 150265399 End Site(bp): 150269580 Gene Summary: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000117362 HGNC ID: HGNC:29509 Entrez Gene: 51107

Expression Profile of APH1A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES NO hsa-let-7b-5p YES YES NO hsa-let-7c-5p YES YES NO hsa-let-7d-5p YES YES NO hsa-let-7e-5p YES YES NO hsa-let-7f-5p YES YES NO hsa-let-7g-5p YES YES NO hsa-let-7i-5p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-1270 YES NO NO hsa-miR-136-5p YES YES NO hsa-miR-138-5p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-182-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-299-3p YES YES NO hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-377-3p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-455-3p YES NO YES hsa-miR-491-5p YES YES YES hsa-miR-506-3p YES YES NO hsa-miR-620 YES NO NO hsa-miR-875-5p YES YES NO hsa-miR-96-5p YES YES NO hsa-miR-98-5p YES YES NO Display: