ctcRbase

Entry Detail

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General Information

Database ID: BRCA01880 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: IDH2 Full Name: isocitrate dehydrogenase (NADP(+)) 2, mitochondrial Category: mRNA Synonyms: D2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 90083045 End Site(bp): 90102504 Gene Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] External Links: Ensembl ID: ENSG00000182054 HGNC ID: HGNC:5383 Entrez Gene: 3418

Expression Profile of IDH2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES NO YES hsa-let-7b-5p YES NO YES hsa-let-7c-5p YES NO YES hsa-let-7d-5p YES NO YES hsa-let-7e-5p YES NO YES hsa-let-7f-5p YES NO YES hsa-let-7g-5p YES NO YES hsa-let-7i-5p YES NO YES hsa-miR-101-3p YES NO YES hsa-miR-144-3p YES YES YES hsa-miR-149-5p YES YES NO hsa-miR-183-5p YES YES YES hsa-miR-340-5p YES NO YES hsa-miR-423-5p YES NO YES hsa-miR-582-5p YES NO YES hsa-miR-98-5p YES NO YES Display: