ctcRbase

Entry Detail

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General Information

Database ID: BRCA02001 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PABPN1 Full Name: poly(A) binding protein nuclear 1 Category: mRNA Synonyms: OPMD|PAB2|PABII|PABP-2|PABP2 Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 23321289 End Site(bp): 23326185 Gene Summary: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. [provided by RefSeq, Dec 2010] External Links: Ensembl ID: ENSG00000100836 HGNC ID: HGNC:8565 Entrez Gene: 8106

Expression Profile of PABPN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-144-3p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-329-3p NO YES YES hsa-miR-330-3p YES NO YES hsa-miR-331-3p YES NO YES hsa-miR-362-3p NO YES YES hsa-miR-371a-5p YES YES NO hsa-miR-379-5p YES YES NO hsa-miR-425-5p YES YES YES hsa-miR-433-3p YES YES NO hsa-miR-488-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-532-3p YES NO YES Display: