ctcRbase

Entry Detail

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General Information

Database ID: BRCA02060 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PCBP1 Full Name: poly(rC) binding protein 1 Category: mRNA Synonyms: HEL-S-85|HNRPE1|HNRPX|hnRNP-E1|hnRNP-X Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 70087454 End Site(bp): 70089203 Gene Summary: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000169564 HGNC ID: HGNC:8647 Entrez Gene: 5093

Expression Profile of PCBP1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1323 YES NO NO hsa-miR-141-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-323a-3p YES NO YES hsa-miR-338-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-490-3p YES YES YES hsa-miR-543 YES YES YES hsa-miR-548o-3p YES NO NO hsa-miR-590-5p YES YES YES hsa-miR-599 YES YES NO Display: