ctcRbase

Entry Detail

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General Information

Database ID: BRCA02130 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: RNASEH1 Full Name: ribonuclease H1 Category: mRNA Synonyms: H1RNA|PEOB2|RNH1 Chromosome: chr2 Strand: - Coordinate: Start Site(bp): 3544793 End Site(bp): 3558616 Gene Summary: This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017] External Links: Ensembl ID: ENSG00000171865 HGNC ID: HGNC:18466 Entrez Gene: 246243

Expression Profile of RNASEH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-144-3p YES YES NO hsa-miR-149-5p YES YES NO hsa-miR-150-5p YES YES NO hsa-miR-216a-5p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-384 YES YES NO hsa-miR-488-3p YES YES NO Display: