ctcRbase

Entry Detail

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General Information

Database ID: BRCA02224 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: CTTN Full Name: cortactin Category: mRNA Synonyms: EMS1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 70398404 End Site(bp): 70436584 Gene Summary: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010] External Links: Ensembl ID: ENSG00000085733 HGNC ID: HGNC:3338 Entrez Gene: 2017

Expression Profile of CTTN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-1271-5p YES YES YES hsa-miR-139-5p YES YES NO hsa-miR-1-3p YES YES NO hsa-miR-142-3p YES NO YES hsa-miR-153-3p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-206 YES YES NO hsa-miR-221-3p YES YES YES hsa-miR-222-3p YES YES YES hsa-miR-326 YES YES NO hsa-miR-329-3p YES NO NO hsa-miR-330-5p YES YES NO hsa-miR-362-3p YES NO NO hsa-miR-382-5p YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-448 YES YES YES hsa-miR-487a-3p YES NO YES hsa-miR-542-3p YES YES NO hsa-miR-613 YES YES NO hsa-miR-875-5p YES YES NO hsa-miR-876-5p YES YES NO hsa-miR-96-5p YES YES YES Display: