ctcRbase

Entry Detail

---



General Information

Database ID: BRCA02238 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: TUBGCP4 Full Name: tubulin gamma complex associated protein 4 Category: mRNA Synonyms: 76P|GCP-4|GCP4|Grip76|MCCRP3 Chromosome: chr15 Strand: + Coordinate: Start Site(bp): 43369221 End Site(bp): 43409771 Gene Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] External Links: Ensembl ID: ENSG00000137822 HGNC ID: HGNC:16691 Entrez Gene: 27229

Expression Profile of TUBGCP4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-147a YES NO NO hsa-miR-183-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-338-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-371a-5p YES YES NO hsa-miR-542-3p NO YES YES Display: