ctcRbase

Entry Detail

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General Information

Database ID: BRCA02267 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: KDELR1 Full Name: KDEL endoplasmic reticulum protein retention receptor 1 Category: mRNA Synonyms: ERD2|ERD2.1|HDEL|PM23 Chromosome: chr19 Strand: - Coordinate: Start Site(bp): 48382570 End Site(bp): 48391553 Gene Summary: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000105438 HGNC ID: HGNC:6304 Entrez Gene: 10945

Expression Profile of KDELR1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-1271-5p YES NO YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-182-5p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-331-3p YES NO YES hsa-miR-335-5p YES YES YES hsa-miR-340-5p YES NO YES hsa-miR-506-3p YES YES NO hsa-miR-96-5p YES NO YES Display: