ctcRbase

Entry Detail

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General Information

Database ID: BRCA02313 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: ACTN4 Full Name: actinin alpha 4 Category: mRNA Synonyms: ACTININ-4|FSGS|FSGS1 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 38647649 End Site(bp): 38731583 Gene Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000130402 HGNC ID: HGNC:166 Entrez Gene: 81

Expression Profile of ACTN4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES YES hsa-miR-129-5p YES YES NO hsa-miR-142-5p YES NO YES hsa-miR-153-3p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-190a-5p YES YES NO hsa-miR-190b YES YES NO hsa-miR-299-5p YES NO YES hsa-miR-324-5p YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-369-3p YES NO YES hsa-miR-371a-5p YES YES NO hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-448 YES NO YES hsa-miR-488-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-520f-3p YES NO YES hsa-miR-599 YES YES NO hsa-miR-758-3p YES YES NO Display: