| ncRNA Symbol: | SDHB |
| Full Name: | succinate dehydrogenase complex iron sulfur subunit B |
| Category: | mRNA |
| Synonyms: | CWS2|IP|PGL4|SDH|SDH1|SDH2|SDHIP |
| Chromosome: | chr1 |
| Strand: | - |
| Coordinate: | | Start Site(bp): | 17018722 | End Site(bp): | 17054170 |
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| Gene Summary: | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008] |
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