ctcRbase

Entry Detail

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General Information

Database ID: BRCA02378 Cancer Type: breast cancer Dataset: GSE75367 CTCs/CTM Isolation Method: micromanipulation immunofluorescence

Gene Information

ncRNA Symbol: ASAH1 Full Name: N-acylsphingosine amidohydrolase 1 Category: mRNA Synonyms: AC|ACDase|ASAH|PHP|PHP32|SMAPME Chromosome: chr8 Strand: - Coordinate: Start Site(bp): 18055992 End Site(bp): 18084998 Gene Summary: This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015] External Links: Ensembl ID: ENSG00000104763 HGNC ID: HGNC:735 Entrez Gene: 427

Expression Profile of ASAH1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-122-5p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-27a-3p YES YES YES hsa-miR-27b-3p YES YES YES hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-490-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520b YES YES NO hsa-miR-520c-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-625-5p YES NO NO hsa-miR-873-5p YES YES NO hsa-miR-93-5p YES YES NO Display: