ctcRbase

Entry Detail

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General Information

Database ID: BRCA02486 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: AXL Full Name: AXL receptor tyrosine kinase Category: mRNA Synonyms: ARK|JTK11|Tyro7|UFO Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 41219203 End Site(bp): 41261766 Gene Summary: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000167601 HGNC ID: HGNC:905 Entrez Gene: 558

Expression Profile of AXL Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-139-5p YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-24-3p YES NO YES hsa-miR-25-3p YES YES YES hsa-miR-324-5p YES YES NO hsa-miR-32-5p YES YES YES hsa-miR-339-5p YES YES NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-491-5p YES YES NO hsa-miR-613 YES YES YES hsa-miR-7-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES hsa-miR-9-5p YES YES NO Display: