ctcRbase

Entry Detail

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General Information

Database ID: BRCA02489 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: CTNNB1 Full Name: catenin beta 1 Category: mRNA Synonyms: CTNNB|EVR7|MRD19|armadillo Chromosome: chr3 Strand: + Coordinate: Start Site(bp): 41194837 End Site(bp): 41260096 Gene Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] External Links: Ensembl ID: ENSG00000168036 HGNC ID: HGNC:2514 Entrez Gene: 1499

Expression Profile of CTNNB1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-139-5p YES NO YES hsa-miR-141-3p YES YES NO hsa-miR-150-5p YES YES YES hsa-miR-181d-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-212-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-320a YES YES NO hsa-miR-320b YES YES NO hsa-miR-320c YES YES NO hsa-miR-320d YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-496 YES YES NO hsa-miR-543 YES YES NO hsa-miR-668-3p YES NO YES hsa-miR-9-5p YES YES NO Display: