ctcRbase

Entry Detail

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General Information

Database ID: BRCA02554 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: PSMC6 Full Name: proteasome 26S subunit, ATPase 6 Category: mRNA Synonyms: SUG2|p42 Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 52707172 End Site(bp): 52728587 Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000100519 HGNC ID: HGNC:9553 Entrez Gene: 5706

Expression Profile of PSMC6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-204-5p YES YES NO hsa-miR-211-5p YES YES NO hsa-miR-224-5p YES YES YES hsa-miR-300 YES YES NO hsa-miR-323a-3p YES NO YES hsa-miR-371a-5p YES YES YES hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-425-5p YES YES NO hsa-miR-495-3p YES YES YES Display: