ctcRbase

Entry Detail

---



General Information

Database ID: BRCA02642 Cancer Type: breast cancer Dataset: GSE55807 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: DYNLT1 Full Name: dynein light chain Tctex-type 1 Category: mRNA Synonyms: CW-1|TCTEL1|tctex-1 Chromosome: chr6 Strand: - Coordinate: Start Site(bp): 158636474 End Site(bp): 158644739 Gene Summary: This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] External Links: Ensembl ID: ENSG00000146425 HGNC ID: HGNC:11697 Entrez Gene: 6993

Expression Profile of DYNLT1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-138-5p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-93-5p YES YES NO Display: