ctcRbase

Entry Detail

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General Information

Database ID: BRCA02648 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: SET Full Name: SET nuclear proto-oncogene Category: mRNA Synonyms: 2PP2A|I2PP2A|IGAAD|IPP2A2|MRD58|PHAPII|TAF-I|TAF-IBETA Chromosome: chr9 Strand: + Coordinate: Start Site(bp): 128683424 End Site(bp): 128696400 Gene Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] External Links: Ensembl ID: ENSG00000119335 HGNC ID: HGNC:10760 Entrez Gene: 6418

Expression Profile of SET Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-128-3p YES YES YES hsa-miR-1297 YES YES NO hsa-miR-145-5p YES YES YES hsa-miR-17-5p YES YES NO hsa-miR-185-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-199a-5p YES YES YES hsa-miR-199b-5p YES YES YES hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-21-5p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-26a-5p YES YES NO hsa-miR-26b-5p YES YES NO hsa-miR-29a-3p YES YES NO hsa-miR-29b-3p YES YES NO hsa-miR-29c-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-330-3p YES NO YES hsa-miR-335-5p YES YES NO hsa-miR-365a-3p YES YES YES hsa-miR-371a-5p YES YES YES hsa-miR-376a-3p YES YES NO hsa-miR-376b-3p YES YES NO hsa-miR-376c-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-496 YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-599 YES YES NO hsa-miR-873-5p YES YES NO hsa-miR-93-5p YES YES NO Display: