ctcRbase

Entry Detail

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General Information

Database ID: BRCA02725 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: ROR1 Full Name: receptor tyrosine kinase like orphan receptor 1 Category: mRNA Synonyms: NTRKR1|dJ537F10.1 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 63774022 End Site(bp): 64181498 Gene Summary: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] External Links: Ensembl ID: ENSG00000185483 HGNC ID: HGNC:10256 Entrez Gene: 4919

Expression Profile of ROR1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-27a-3p YES NO YES hsa-miR-27b-3p YES NO YES hsa-miR-340-5p YES YES NO hsa-miR-346 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-543 YES YES NO Display: