ctcRbase

Entry Detail

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General Information

Database ID: BRCA02802 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: APLP2 Full Name: amyloid beta precursor like protein 2 Category: mRNA Synonyms: APLP-2|APPH|APPL2|CDEBP Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 130069837 End Site(bp): 130144811 Gene Summary: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] External Links: Ensembl ID: ENSG00000084234 HGNC ID: HGNC:598 Entrez Gene: 334

Expression Profile of APLP2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES YES hsa-miR-128-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-139-5p YES YES YES hsa-miR-140-3p YES NO YES hsa-miR-141-3p YES YES NO hsa-miR-144-3p YES YES YES hsa-miR-153-3p YES YES YES hsa-miR-15a-5p YES NO NO hsa-miR-181a-5p YES NO YES hsa-miR-181b-5p YES NO YES hsa-miR-181c-5p YES NO YES hsa-miR-181d-5p YES NO YES hsa-miR-186-5p YES NO NO hsa-miR-199a-3p YES NO YES hsa-miR-199b-3p YES NO YES hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-216b-5p YES YES NO hsa-miR-27a-3p YES YES NO hsa-miR-27b-3p YES YES NO hsa-miR-30a-5p YES YES NO hsa-miR-30b-5p YES YES NO hsa-miR-30c-5p YES YES NO hsa-miR-30d-5p YES YES NO hsa-miR-30e-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-378a-3p YES YES NO hsa-miR-409-5p YES NO YES hsa-miR-422a YES YES NO hsa-miR-429 YES YES YES hsa-miR-448 YES YES NO hsa-miR-450a-5p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-497-5p YES NO NO hsa-miR-542-3p YES YES NO Display: