ctcRbase

Entry Detail

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General Information

Database ID: BRCA02958 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: NECTIN4 Full Name: nectin cell adhesion molecule 4 Category: mRNA Synonyms: EDSS1|LNIR|PRR4|PVRL4|nectin-4 Chromosome: chr1 Strand: - Coordinate: Start Site(bp): 161070995 End Site(bp): 161089599 Gene Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011] External Links: Ensembl ID: ENSG00000143217 HGNC ID: HGNC:19688 Entrez Gene: 81607

Expression Profile of NECTIN4 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-128-3p YES YES YES hsa-miR-185-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-296-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-326 YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-330-5p YES YES YES hsa-miR-342-3p YES YES YES hsa-miR-362-3p YES NO NO hsa-miR-377-3p YES NO YES hsa-miR-381-3p YES YES NO hsa-miR-421 YES YES NO hsa-miR-429 YES YES YES hsa-miR-505-3p YES YES NO Display: