ctcRbase

Entry Detail

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General Information

Database ID: BRCA02962 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: NOG Full Name: noggin Category: mRNA Synonyms: SYM1|SYNS1|SYNS1A Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 56593699 End Site(bp): 56595590 Gene Summary: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000183691 HGNC ID: HGNC:7866 Entrez Gene: 9241

Expression Profile of NOG Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p NO YES YES hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-144-3p NO YES YES hsa-miR-148a-3p YES YES YES hsa-miR-148b-3p YES YES YES hsa-miR-152-3p YES YES YES hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-186-5p NO YES YES hsa-miR-192-5p YES YES NO hsa-miR-200b-3p YES YES YES hsa-miR-200c-3p YES YES YES hsa-miR-215-5p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-340-5p NO YES YES hsa-miR-362-3p YES YES NO hsa-miR-369-3p YES NO YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-384 YES YES NO hsa-miR-429 YES YES YES hsa-miR-454-3p YES YES NO hsa-miR-873-5p YES YES NO Display: