ctcRbase

Entry Detail

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General Information

Database ID: BRCA03006 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: HERPUD1 Full Name: homocysteine inducible ER protein with ubiquitin like domain 1 Category: mRNA Synonyms: HERP|Mif1|SUP Chromosome: chr16 Strand: + Coordinate: Start Site(bp): 56932048 End Site(bp): 56944863 Gene Summary: The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013] External Links: Ensembl ID: ENSG00000051108 HGNC ID: HGNC:13744 Entrez Gene: 9709

Expression Profile of HERPUD1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-126-3p YES YES YES hsa-miR-142-5p YES NO YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-197-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-217 YES YES YES hsa-miR-320a YES YES YES hsa-miR-320b YES YES YES hsa-miR-320c YES YES YES hsa-miR-320d YES YES YES hsa-miR-329-3p YES NO NO hsa-miR-33a-5p YES YES NO hsa-miR-33b-5p YES YES NO hsa-miR-340-5p YES YES YES hsa-miR-362-3p YES NO NO hsa-miR-370-3p YES YES YES hsa-miR-375 YES NO YES hsa-miR-376a-3p YES NO YES hsa-miR-376b-3p YES NO YES hsa-miR-376c-3p YES YES NO hsa-miR-384 YES YES YES hsa-miR-410-3p YES YES YES hsa-miR-455-3p YES NO YES hsa-miR-487b-3p YES YES YES hsa-miR-496 YES YES NO hsa-miR-543 YES YES YES hsa-miR-873-5p YES YES NO Display: