ctcRbase

Entry Detail

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General Information

Database ID: BRCA03128 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: DAAM1 Full Name: dishevelled associated activator of morphogenesis 1 Category: mRNA Synonyms: - Chromosome: chr14 Strand: + Coordinate: Start Site(bp): 59188646 End Site(bp): 59371405 Gene Summary: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012] External Links: Ensembl ID: ENSG00000100592 HGNC ID: HGNC:18142 Entrez Gene: 23002

Expression Profile of DAAM1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-132-3p YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-145-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-206 YES YES YES hsa-miR-212-3p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-329-3p YES YES NO hsa-miR-335-5p YES YES YES hsa-miR-34a-5p YES YES YES hsa-miR-34c-5p YES YES YES hsa-miR-362-3p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-375 YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-449a YES YES YES hsa-miR-449b-5p YES YES YES hsa-miR-613 YES YES YES hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO Display: