ctcRbase

Entry Detail

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General Information

Database ID: BRCA03169 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: RTN3 Full Name: reticulon 3 Category: mRNA Synonyms: ASYIP|HAP|NSPL2|NSPLII|RTN3-A1 Chromosome: chr11 Strand: + Coordinate: Start Site(bp): 63681446 End Site(bp): 63759891 Gene Summary: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012] External Links: Ensembl ID: ENSG00000133318 HGNC ID: HGNC:10469 Entrez Gene: 10313

Expression Profile of RTN3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES NO hsa-miR-1-3p YES NO YES hsa-miR-140-3p YES NO YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-205-5p YES YES YES hsa-miR-206 YES NO YES hsa-miR-218-5p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-361-5p YES YES NO hsa-miR-371a-5p YES YES YES hsa-miR-424-5p YES YES NO hsa-miR-496 YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-499a-5p YES YES NO hsa-miR-506-3p YES NO YES hsa-miR-613 YES NO YES hsa-miR-655-3p YES NO YES hsa-miR-873-5p YES YES YES Display: