ctcRbase

Entry Detail

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General Information

Database ID: BRCA03271 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: ILF3 Full Name: interleukin enhancer binding factor 3 Category: mRNA Synonyms: CBTF|DRBF|DRBP76|MMP4|MPHOSPH4|MPP4|NF-AT-90|NF110|NF110b|NF90|NF90a|NF90b|NFAR|NFAR-1|NFAR2|TCP110|TCP80 Chromosome: chr19 Strand: + Coordinate: Start Site(bp): 10654261 End Site(bp): 10692417 Gene Summary: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000129351 HGNC ID: HGNC:6038 Entrez Gene: 3609

Expression Profile of ILF3 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-1271-5p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-129-5p YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-136-5p YES YES NO hsa-miR-154-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-181a-5p YES YES YES hsa-miR-181b-5p YES YES YES hsa-miR-181c-5p YES YES YES hsa-miR-181d-5p YES YES YES hsa-miR-183-5p YES YES NO hsa-miR-196a-5p YES YES NO hsa-miR-196b-5p YES YES NO hsa-miR-19a-3p NO YES YES hsa-miR-19b-3p NO YES YES hsa-miR-208a-3p YES YES NO hsa-miR-208b-3p YES YES NO hsa-miR-224-5p NO YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-326 YES YES NO hsa-miR-330-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-370-3p YES YES NO hsa-miR-371a-5p YES YES YES hsa-miR-379-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-382-5p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-433-3p NO YES YES hsa-miR-490-3p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES YES hsa-miR-499a-5p YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-599 YES YES NO hsa-miR-7-5p NO YES YES hsa-miR-9-5p YES YES NO hsa-miR-96-5p YES YES NO Display: