ctcRbase

Entry Detail

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General Information

Database ID: BRCA03282 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: TGIF1 Full Name: TGFB induced factor homeobox 1 Category: mRNA Synonyms: HPE4|TGIF Chromosome: chr18 Strand: + Coordinate: Start Site(bp): 3411608 End Site(bp): 3459978 Gene Summary: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013] External Links: Ensembl ID: ENSG00000177426 HGNC ID: HGNC:11776 Entrez Gene: 7050

Expression Profile of TGIF1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-101-3p YES YES NO hsa-miR-124-3p YES YES NO hsa-miR-128-3p YES YES NO hsa-miR-139-5p YES YES YES hsa-miR-1-3p YES YES YES hsa-miR-144-3p YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-155-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-194-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-206 YES YES YES hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-25-3p YES YES YES hsa-miR-299-3p YES YES YES hsa-miR-32-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-342-3p YES YES NO hsa-miR-363-3p YES YES YES hsa-miR-367-3p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-433-3p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-494-3p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-543 YES YES NO hsa-miR-613 YES YES YES hsa-miR-873-5p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES YES Display: