| ncRNA Symbol: | ATIC |
| Full Name: | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
| Category: | mRNA |
| Synonyms: | AICAR|AICARFT|HEL-S-70p|IMPCHASE|PURH |
| Chromosome: | chr2 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 215311817 | End Site(bp): | 215349773 |
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| Gene Summary: | This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009] |
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