ctcRbase

Entry Detail

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General Information

Database ID: BRCA03298 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: HS3ST3B1 Full Name: heparan sulfate-glucosamine 3-sulfotransferase 3B1 Category: mRNA Synonyms: 3-OST-3B|3OST3B1|h3-OST-3B Chromosome: chr17 Strand: + Coordinate: Start Site(bp): 14301083 End Site(bp): 14349404 Gene Summary: The protein encoded by this gene is a type II integral membrane protein that belongs to the 3-O-sulfotransferases family. These proteins catalyze the addition of sulfate groups at the 3-OH position of glucosamine in heparan sulfate. The substrate specificity of individual members of the family is based on prior modification of the heparan sulfate chain, thus allowing different members of the family to generate binding sites for different proteins on the same heparan sulfate chain. Following treatment with a histone deacetylase inhibitor, expression of this gene is activated in a pancreatic cell line. The increased expression results in promotion of the epithelial-mesenchymal transition. In addition, the modification catalyzed by this protein allows herpes simplex virus membrane fusion and penetration. A very closely related homolog with an almost identical sulfotransferase domain maps less than 1 Mb away. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] External Links: Ensembl ID: ENSG00000125430 HGNC ID: HGNC:5198 Entrez Gene: 9953

Expression Profile of HS3ST3B1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-100-5p YES YES YES hsa-miR-1297 YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-1-3p YES YES YES hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-206 YES YES YES hsa-miR-216a-5p YES YES YES hsa-miR-216b-5p YES NO YES hsa-miR-218-5p YES YES YES hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-29a-3p YES YES YES hsa-miR-29b-3p YES YES YES hsa-miR-29c-3p YES YES YES hsa-miR-340-5p YES YES YES hsa-miR-382-5p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-485-5p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-613 YES YES YES hsa-miR-641 YES NO NO hsa-miR-99a-5p YES YES YES hsa-miR-99b-5p YES YES YES Display: