ctcRbase

Entry Detail

---



General Information

Database ID: BRCA03423 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: ACTN1 Full Name: actinin alpha 1 Category: mRNA Synonyms: BDPLT15 Chromosome: chr14 Strand: - Coordinate: Start Site(bp): 68874143 End Site(bp): 68979440 Gene Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] External Links: Ensembl ID: ENSG00000072110 HGNC ID: HGNC:163 Entrez Gene: 87

Expression Profile of ACTN1 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-129-5p YES YES YES hsa-miR-19a-3p YES YES YES hsa-miR-19b-3p YES YES YES hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-214-3p YES YES NO hsa-miR-218-5p YES YES YES hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-374a-5p YES YES YES hsa-miR-374b-5p YES YES YES hsa-miR-410-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-501-3p YES NO YES hsa-miR-502-3p YES NO YES Display: