ctcRbase

Entry Detail

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General Information

Database ID: BRCA03482 Cancer Type: breast cancer Dataset: GSE111065 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MTHFD2 Full Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Category: mRNA Synonyms: NMDMC Chromosome: chr2 Strand: + Coordinate: Start Site(bp): 74198562 End Site(bp): 74217565 Gene Summary: This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] External Links: Ensembl ID: ENSG00000065911 HGNC ID: HGNC:7434 Entrez Gene: 10797

Expression Profile of MTHFD2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-124-3p YES YES NO hsa-miR-1251-5p YES NO YES hsa-miR-137 YES YES NO hsa-miR-146a-5p YES YES NO hsa-miR-146b-5p YES YES NO hsa-miR-186-5p YES NO NO hsa-miR-22-3p YES YES YES hsa-miR-25-3p YES YES NO hsa-miR-300 YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-33a-5p YES YES YES hsa-miR-33b-5p YES YES YES hsa-miR-340-5p YES YES NO hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES YES hsa-miR-371a-5p YES YES NO hsa-miR-381-3p YES YES NO hsa-miR-383-5p YES YES NO hsa-miR-384 YES YES NO hsa-miR-410-3p YES YES NO hsa-miR-411-5p YES YES NO hsa-miR-421 YES YES NO hsa-miR-496 YES YES NO hsa-miR-505-3p YES YES NO hsa-miR-506-3p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-92a-3p YES YES YES hsa-miR-92b-3p YES YES NO hsa-miR-9-5p YES YES YES Display: