ctcRbase

Entry Detail

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General Information

Database ID: BRCA03526 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PTPN2 Full Name: protein tyrosine phosphatase, non-receptor type 2 Category: mRNA Synonyms: PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP Chromosome: chr18 Strand: - Coordinate: Start Site(bp): 12785478 End Site(bp): 12929643 Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011] External Links: Ensembl ID: ENSG00000175354 HGNC ID: HGNC:9650 Entrez Gene: 5771

Expression Profile of PTPN2 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-106a-5p YES YES NO hsa-miR-106b-5p YES YES NO hsa-miR-10a-5p YES YES NO hsa-miR-10b-5p YES YES NO hsa-miR-125a-5p YES YES NO hsa-miR-125b-5p YES YES NO hsa-miR-134-5p YES YES NO hsa-miR-137 YES YES YES hsa-miR-138-5p YES YES YES hsa-miR-141-3p YES YES NO hsa-miR-153-3p YES YES NO hsa-miR-17-5p YES YES NO hsa-miR-186-5p YES YES NO hsa-miR-200a-3p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-20a-5p YES YES NO hsa-miR-20b-5p YES YES NO hsa-miR-223-3p YES YES NO hsa-miR-22-3p YES YES NO hsa-miR-302a-3p YES YES NO hsa-miR-302b-3p YES YES NO hsa-miR-302c-3p YES YES NO hsa-miR-302d-3p YES YES NO hsa-miR-302e YES YES NO hsa-miR-30a-5p YES YES YES hsa-miR-30b-5p YES YES YES hsa-miR-30c-5p YES YES YES hsa-miR-30d-5p YES YES YES hsa-miR-30e-5p YES YES YES hsa-miR-329-3p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-362-3p YES YES NO hsa-miR-372-3p YES YES NO hsa-miR-373-3p YES YES NO hsa-miR-429 YES YES NO hsa-miR-431-5p YES YES NO hsa-miR-448 YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-519d-3p YES YES NO hsa-miR-520a-3p YES YES NO hsa-miR-520d-3p YES YES NO hsa-miR-520e YES YES NO hsa-miR-653-5p YES YES NO hsa-miR-758-3p YES YES NO hsa-miR-93-5p YES YES NO Display: