ctcRbase

Entry Detail

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General Information

Database ID: BRCA03531 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: NCSTN Full Name: nicastrin Category: mRNA Synonyms: ATAG1874 Chromosome: chr1 Strand: + Coordinate: Start Site(bp): 160343272 End Site(bp): 160358952 Gene Summary: This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014] External Links: Ensembl ID: ENSG00000162736 HGNC ID: HGNC:17091 Entrez Gene: 23385

Expression Profile of NCSTN Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-140-5p YES YES YES hsa-miR-145-5p YES NO YES hsa-miR-199a-5p YES NO YES hsa-miR-199b-5p YES NO YES hsa-miR-21-5p YES YES NO hsa-miR-24-3p YES YES NO hsa-miR-31-5p YES YES NO hsa-miR-339-5p YES YES NO hsa-miR-455-5p YES YES NO hsa-miR-495-3p YES YES NO hsa-miR-590-5p YES YES NO hsa-miR-599 YES YES NO Display: