ctcRbase

Entry Detail

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General Information

Database ID: BRCA03544 Cancer Type: breast cancer Dataset: GSE86978 CTCs/CTM Isolation Method: CTC-iChip

Gene Information

ncRNA Symbol: CDKN1A Full Name: cyclin dependent kinase inhibitor 1A Category: mRNA Synonyms: CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 Chromosome: chr6 Strand: + Coordinate: Start Site(bp): 36676460 End Site(bp): 36687339 Gene Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015] External Links: Ensembl ID: ENSG00000124762 HGNC ID: HGNC:1784 Entrez Gene: 1026

Expression Profile of CDKN1A Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-let-7a-5p YES YES YES hsa-let-7b-5p YES YES YES hsa-let-7c-5p YES YES YES hsa-let-7d-5p YES YES YES hsa-let-7e-5p YES YES YES hsa-let-7f-5p YES YES YES hsa-let-7g-5p YES YES YES hsa-let-7i-5p YES YES YES hsa-miR-101-3p YES YES NO hsa-miR-106a-5p YES YES YES hsa-miR-106b-5p YES YES YES hsa-miR-130a-3p YES YES YES hsa-miR-130b-3p YES YES YES hsa-miR-132-3p YES YES YES hsa-miR-17-5p YES YES YES hsa-miR-186-5p YES YES NO hsa-miR-208a-3p YES NO YES hsa-miR-208b-3p YES NO YES hsa-miR-20a-5p YES YES YES hsa-miR-20b-5p YES YES YES hsa-miR-212-3p YES YES YES hsa-miR-22-3p YES YES NO hsa-miR-224-5p YES YES NO hsa-miR-28-5p YES YES NO hsa-miR-301a-3p YES YES YES hsa-miR-301b-3p YES YES YES hsa-miR-335-5p YES YES NO hsa-miR-365a-3p YES YES NO hsa-miR-370-3p YES YES YES hsa-miR-379-5p YES YES NO hsa-miR-454-3p YES YES YES hsa-miR-485-5p YES YES YES hsa-miR-491-5p YES YES NO hsa-miR-499a-5p YES NO YES hsa-miR-519d-3p YES YES YES hsa-miR-582-5p YES NO YES hsa-miR-708-5p YES YES NO hsa-miR-93-5p YES YES YES hsa-miR-98-5p YES YES YES Display: