ctcRbase

Entry Detail

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General Information

Database ID: BRCA03588 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: PCSK6 Full Name: proprotein convertase subtilisin/kexin type 6 Category: mRNA Synonyms: PACE4|SPC4 Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 101297142 End Site(bp): 101525202 Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014] External Links: Ensembl ID: ENSG00000140479 HGNC ID: HGNC:8569 Entrez Gene: 5046

Expression Profile of PCSK6 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-103a-3p YES YES NO hsa-miR-107 YES YES NO hsa-miR-130a-3p YES YES NO hsa-miR-130b-3p YES YES NO hsa-miR-133a-3p YES NO YES hsa-miR-133b YES NO YES hsa-miR-148a-3p YES YES NO hsa-miR-148b-3p YES YES NO hsa-miR-152-3p YES YES NO hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-19a-3p YES YES NO hsa-miR-19b-3p YES YES NO hsa-miR-21-5p YES YES YES hsa-miR-218-5p YES YES NO hsa-miR-25-3p YES YES NO hsa-miR-301a-3p YES YES NO hsa-miR-301b-3p YES YES NO hsa-miR-32-5p YES YES NO hsa-miR-328-3p YES YES NO hsa-miR-340-5p YES NO YES hsa-miR-363-3p YES YES NO hsa-miR-367-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-454-3p YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-496 YES YES NO hsa-miR-497-5p YES YES NO hsa-miR-543 YES YES NO hsa-miR-590-5p YES YES YES hsa-miR-7-5p YES YES NO hsa-miR-92a-3p YES YES NO hsa-miR-92b-3p YES YES NO hsa-miR-9-5p YES YES YES Display: