ctcRbase

Entry Detail

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General Information

Database ID: BRCA03754 Cancer Type: breast cancer Dataset: GSE41245 CTCs/CTM Isolation Method: CTC-Chip

Gene Information

ncRNA Symbol: HEXA Full Name: hexosaminidase subunit alpha Category: mRNA Synonyms: TSD Chromosome: chr15 Strand: - Coordinate: Start Site(bp): 72340919 End Site(bp): 72376476 Gene Summary: This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016] External Links: Ensembl ID: ENSG00000213614 HGNC ID: HGNC:4878 Entrez Gene: 3073

Expression Profile of HEXA Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-15a-5p YES YES NO hsa-miR-15b-5p YES YES NO hsa-miR-16-5p YES YES NO hsa-miR-195-5p YES YES NO hsa-miR-340-5p YES YES NO hsa-miR-377-3p YES YES NO hsa-miR-424-5p YES YES NO hsa-miR-497-5p YES YES NO Display: