ctcRbase

Entry Detail

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General Information

Database ID: BRCA03786 Cancer Type: breast cancer Dataset: GSE109761 CTCs/CTM Isolation Method: microfluidics immunofluorescence

Gene Information

ncRNA Symbol: MRPS35 Full Name: mitochondrial ribosomal protein S35 Category: mRNA Synonyms: HDCMD11P|MDS023|MRP-S28|MRPS28 Chromosome: chr12 Strand: + Coordinate: Start Site(bp): 27710773 End Site(bp): 27756295 Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010] External Links: Ensembl ID: ENSG00000061794 HGNC ID: HGNC:16635 Entrez Gene: 60488

Expression Profile of MRPS35 Gene

 

Regulatory Relationship

mRNA targets: NA miRNA targets: miRNA Name PITA miRanda RNAhybrid hsa-miR-154-5p YES YES NO hsa-miR-181a-5p YES YES NO hsa-miR-181b-5p YES YES NO hsa-miR-181c-5p YES YES NO hsa-miR-181d-5p YES YES NO hsa-miR-199a-5p YES YES NO hsa-miR-199b-5p YES YES NO hsa-miR-200b-3p YES YES NO hsa-miR-200c-3p YES YES NO hsa-miR-221-3p YES YES NO hsa-miR-222-3p YES YES NO hsa-miR-23a-3p YES YES NO hsa-miR-23b-3p YES YES NO hsa-miR-28-5p NO YES YES hsa-miR-328-3p YES YES NO hsa-miR-346 NO YES YES hsa-miR-429 YES YES NO hsa-miR-491-5p YES YES NO hsa-miR-499a-5p NO YES YES hsa-miR-543 YES YES NO hsa-miR-708-5p NO YES YES Display: