| ncRNA Symbol: | LGI1 |
| Full Name: | leucine rich glioma inactivated 1 |
| Category: | mRNA |
| Synonyms: | ADLTE|ADPAEF|ADPEAF|EPITEMPIN|EPT|ETL1|IB1099 |
| Chromosome: | chr10 |
| Strand: | + |
| Coordinate: | | Start Site(bp): | 93757809 | End Site(bp): | 93806272 |
|
| Gene Summary: | This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| External Links: | |